Adipotide, also called Prohibitin-targeting peptide 1, is a 25-amino acid peptide designed to attach to a protein called prohibitin [1]. Prohibitin protein is multi-functional, with roles in cell growth and survival, and apoptosis. It is found in several cellular compartments, including the cell membrane [1].
Adipotide peptide has three main components [2]:
It works mainly by targeting specific blood vessels that supply white fat tissue, cutting off fat cell oxygen and nutrient supply, and leading to apoptosis [1]. This approach is highly selective, sparing other tissues [1].
Adipotide peptide kills fat cells indirectly, by attacking the blood vessels that keep fat tissue alive rather than killing the fat cells outright [2].
Adipotide has a homing sequence that specifically binds prohibitin and ANXA2 proteins, which are found on the surface of endothelial cells that line blood vessels supplying fat tissue [2]. This makes the peptide highly selective for fat tissue vasculature [3].
Once bound to prohibitin, the peptide is pulled into endothelial cells and disrupts mitochondria to cause cell death [4]. With the blood vessel destroyed, fat cells lose their supply of oxygen and nutrients [2]. This ischemic stress triggers a secondary apoptosis in the fat cells themselves, leading to resorption of white fat tissue [2].
In short, Adipotide kills the support system that fat cells rely on, causing them to die and be broken down by the body [2]. This process also seems to improve brain signals that reduce appetite and further enhance fat loss [3].
Adipotide peptide acts to reduce white fat mass, impacting metabolic health by augmenting the processing and response to insulin [2]. When adipotide peptide destroys blood vessels that feed adipose tissue, the fat cells gradually die and are resorbed by the body [1]. This shrinking of fat tissue can impact the release of certain inflammatory and hormone-like molecules, called adipokines, which are linked to insulin resistance [2].
In animal studies, adipokine peptide lowered fasting insulin levels without changing blood sugar levels, suggesting that the body became more sensitive to insulin and did not need to overproduce it to control blood sugar levels [3].
Rodent studies also found that adipotide-induced fat loss did not trigger the typical drop in metabolic rate that often accompanies weight loss [3]. In some cases, energy expenditure even increased [3]. This means the body continues burning calories at the same or even slightly higher rate. This helped sustain weight loss and maintain metabolic improvements.
By reducing fat mass, improving insulin sensitivity, and potentially maintaining or even boosting energy use, adipotide peptide directly addresses key metabolic problems associated with weight management [3].
Adipotide peptide acts on blood vessels via a two-part mechanism that is highly selective for those that supply white fat tissue [2].
The first part is a “homing” sequence of amino acids (CKGGRAKDC) that recognizes and binds to prohibitin, a protein located on the surface of cells that line blood vessels in white adipose tissue [2]. This targeting is very specific – prohibitin is especially accessible in the vasculature of white fat, making it a unique marker for those blood vessels [2].
Once bound to prohibitin, the peptide is taken inside endothelial cells [2]. Attached to the targeting sequence is a proapoptotic peptide (D[KLAKLAK]₂) that disrupts the cell's mitochondria (structures that produce energy) [2]. This mitochondrial damage activates apoptosis, or programmed cell death, in endothelial cells [2].
When enough endothelial cells in a vessel die, the blood vessel collapses and is destroyed [2]. Without such vascular supply, white fat tissue loses both oxygen and nutrient flow, causing a breakdown and resorption of fat [2].
Research Use Only. All findings described above are derived from preclinical studies (animal models and in vitro experiments). Adipotide is not approved by the FDA for any diagnostic or therapeutic use in humans. Genesis Peptides makes no claims regarding human clinical efficacy. This product is sold exclusively for laboratory research.
Every lot undergoes five independent assays before release. Results are published in the lot-specific Certificate of Analysis.
Every lot undergoes our 4-panel testing protocol: HPLC purity analysis, ESI-MS identity confirmation, LAL endotoxin screening, and amino acid analysis (for peptides >15 residues). Full analytical data is published in the Certificate of Analysis for each lot.
Lyophilized peptides should be stored at -20°C or below for long-term stability. Once reconstituted, peptides should be stored at 2–8°C and used within a reasonable timeframe depending on the specific compound. Avoid repeated freeze-thaw cycles. Always store in a dry environment away from direct light.
Orders placed before noon PST, Monday–Saturday, ship the same day. We offer free standard shipping on orders over $150. All orders are shipped in insulated packaging with ice packs when necessary. Standard delivery typically takes 2–4 business days within the continental US.
No. All compounds sold by Genesis Peptides are strictly for in vitro and preclinical laboratory research purposes only. They are not approved for human consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm the products will be used solely for legitimate research applications.
A Certificate of Analysis (COA) is a document issued by our analytical laboratory that reports the results of all quality control tests performed on a specific lot of product. Each COA includes HPLC chromatograms, mass spectra, endotoxin results, and amino acid analysis where applicable. COAs are available in our COA Library for every lot we have shipped.
Yes. We offer volume pricing for universities, research institutions, and laboratories with recurring needs. Discounts begin at 10+ units and scale with volume. Contact our team for a custom quote tailored to your research requirements.
FOR RESEARCH USE ONLY — Products are sold exclusively for in vitro and preclinical laboratory research. Not for human consumption or administration. Not intended for diagnostic or therapeutic use. These statements have not been evaluated by the FDA.