Melanotan I, a synthetic analogue of α-MSH, acts as an agonist on melanocortin receptors, primarily MC1R [1]. This receptor plays an important role in normal skin pigmentation, found on the surface of skin pigment cells (melanocytes) [1]. Compared to Melanotan II, Melanotan I has a longer duration of action and is more resistant to enzymatic breakdown [2]. Because of its selectivity for MC1R, Melanotan I primarily influences skin pigmentation with minimal central nervous system penetration [2].
Melanotan I stimulates tanning by binding to MC1R receptors in skin cells, increasing the production of eumelanin, the dark pigment that protects against UV damage [3]. This process enhances photoprotection. Conversely, those with mutations to this receptor produce more pheomelanin, tend to tan poorly, and have an increased risk for sunburn and skin cancer [4]. Melanotan I has been explored for photoprotection in those with these genetic conditions that heighten UV sensitivity [5].
Phase 1 studies have been conducted on Melanotan 1, in which participants received daily injections across 1-4 weeks and then exposed to limited UV-B or sunlight on specific parts of their skin [6]. Those who received the injections developed faster, darker tans than those exposed to light alone, which lasted three weeks longer and required less sun exposure to achieve. They also showed fewer sunburned skin cells, suggesting better skin protection.
Preliminary research has suggested that melanocortin activation may influence neuroprotective pathways in the brain through anti-inflammatory and neuroprotective actions. Animal studies show reductions in brain damage, improved recovery, and limited inflammation when given soon after a stroke [7].
A phase IIa clinical trial found that Melanotan I was safe and well-tolerated in patients who suffered strokes, with no serious side effects [7]. Most patients had improved brain scans and neurological recovery, suggesting a role in protecting brain tissue, stabilizing the blood-brain barrier, and supporting neuroplasticity even when administered up to 20 hours after stroke onset [7].
By mimicking the effects of α-MSH, Melanotan 1 may help support vascular health by improving endothelial function and nitric oxide production, which supports blood vessel relaxation [8]. Activation of MC1 receptors found on endothelial cells may enhance circulation, reduce stiffness, and protect against vascular dysfunction associated with metabolic stress [8]. However, current data is sparse. Unlike Melanotan II, it does not significantly activate central melanocortin receptors involved in autonomic control.
Research Use Only. All findings described above are derived from preclinical studies (animal models and in vitro experiments). Melanotan 1 is not approved by the FDA for any diagnostic or therapeutic use in humans. Genesis Peptides makes no claims regarding human clinical efficacy. This product is sold exclusively for laboratory research.
Every lot undergoes five independent assays before release. Results are published in the lot-specific Certificate of Analysis.
Every lot undergoes our 4-panel testing protocol: HPLC purity analysis, ESI-MS identity confirmation, LAL endotoxin screening, and amino acid analysis (for peptides >15 residues). Full analytical data is published in the Certificate of Analysis for each lot.
Lyophilized peptides should be stored at -20°C or below for long-term stability. Once reconstituted, peptides should be stored at 2–8°C and used within a reasonable timeframe depending on the specific compound. Avoid repeated freeze-thaw cycles. Always store in a dry environment away from direct light.
Orders placed before noon PST, Monday–Saturday, ship the same day. We offer free standard shipping on orders over $150. All orders are shipped in insulated packaging with ice packs when necessary. Standard delivery typically takes 2–4 business days within the continental US.
No. All compounds sold by Genesis Peptides are strictly for in vitro and preclinical laboratory research purposes only. They are not approved for human consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm the products will be used solely for legitimate research applications.
A Certificate of Analysis (COA) is a document issued by our analytical laboratory that reports the results of all quality control tests performed on a specific lot of product. Each COA includes HPLC chromatograms, mass spectra, endotoxin results, and amino acid analysis where applicable. COAs are available in our COA Library for every lot we have shipped.
Yes. We offer volume pricing for universities, research institutions, and laboratories with recurring needs. Discounts begin at 10+ units and scale with volume. Contact our team for a custom quote tailored to your research requirements.
FOR RESEARCH USE ONLY — Products are sold exclusively for in vitro and preclinical laboratory research. Not for human consumption or administration. Not intended for diagnostic or therapeutic use. These statements have not been evaluated by the FDA.