MOTS-C
$95.00
MOTS-c, short for Mitochondrial Open Reading Frame of the Twelve S rRNA-c, is a bioactive peptide originating from the mitochondrial DNA (mtDNA) (Lee et al., 2015). This peptide, consisting of 16 amino acids, was discovered by researchers at the University of Southern California (USC) Leonard Davis School of Gerontology, with its unique ability to regulate metabolic processes and potentially mitigate metabolic diseases such as obesity and type 2 diabetes (Lee et al., 2015; Zheng et al., 2020).
What is MOTS-c?
MOTS-c, short for Mitochondrial Open Reading Frame of the Twelve S rRNA-c, is a bioactive peptide originating from the mitochondrial DNA (mtDNA) (Lee et al., 2015). This peptide, consisting of 16 amino acids, was discovered by researchers at the University of Southern California (USC) Leonard Davis School of Gerontology, with its unique ability to regulate metabolic processes and potentially mitigate metabolic diseases such as obesity and type 2 diabetes (Lee et al., 2015; Zheng et al., 2020).
What is the Key Mechanism of MOTS-c?
MOTS-c exerts its functions primarily by interacting with the metabolic machinery in skeletal muscle (Lee et al., 2015). It has been found to enhance insulin sensitivity, maintain metabolic balance, and promote energy expenditure, thereby counteracting diet-induced and age-related metabolic disorders (Lee et al., 2015; Yen et al., 2013).
What are the benefits of MOTS-c?
MOTS-c and Metabolic Regulation: Research has indicated that MOTS-c plays an active role in regulating metabolic function. Its capability to promote metabolic homeostasis and insulin sensitivity has raised interest in its potential use in managing conditions like obesity and type 2 diabetes (Lee et al., 2015; Zheng et al., 2020).
MOTS-c and Aging: MOTS-c’s role in metabolic regulation has implications for aging. It is suggested that this peptide might be instrumental in mitigating age-related metabolic decline and therefore promoting longevity (Kim et al., 2018).
MOTS-c and Obesity: In preclinical studies, MOTS-c has demonstrated the ability to inhibit diet-induced obesity by promoting metabolic function and fat oxidation, suggesting its potential application in weight management (Lee et al., 2015).
References:
Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., … & Cohen, P. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443-454. doi: 10.1016/j.cmet.2015.02.009.
Kim, S. J., Guerrero, N., Wassef, G., Xiao, J., Mehta, H. H., Cohen, P., & Yen, K. (2018). The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiological Reports, 6(14), e13762. doi: 10.14814/phy2.13762.
Zheng, Y., Liu, P., Wang, N., Wang, S., Yang, B., Li, M., & Chen, J. (2020). A novel mitochondrial-derived peptide, MOTS-c, attenuates high-glucose-induced oxidative stress in RPE cells via AMPK signaling pathway. Experimental Eye Research, 197, 108094. doi: 10.1016/j.exer.2020.108094.
Yen, K., Wan, J., Mehta, H. H., Miller, B., Christensen, A., Levine, M. E., … & Cohen, P. (2013). Humanin prevents age-related cognitive decline in mice and is associated with improved cognitive age in humans. Scientific reports, 8(1), 1-10. doi: 10.1038/s41598-018-21049-1.
