Sermorelin

$45.00

Sermorelin is a synthetic peptide analogous to the naturally occurring growth hormone-releasing hormone (GHRH) (Walker, 2006). Composed of 29 amino acids, it acts on the pituitary gland, specifically stimulating the production and release of growth hormone (GH) (Kassem et al., 1999). The clinical and scientific utility of Sermorelin extends to diagnosing and managing growth hormone deficiencies, as well as investigating the potential effects of GH on mitigating symptoms of aging (Walker, 2006).

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What is Sermorelin?

Sermorelin is a synthetic peptide analogous to the naturally occurring growth hormone-releasing hormone (GHRH) (Walker, 2006). Composed of 29 amino acids, it acts on the pituitary gland, specifically stimulating the production and release of growth hormone (GH) (Kassem et al., 1999).

The clinical and scientific utility of Sermorelin extends to diagnosing and managing growth hormone deficiencies, as well as investigating the potential effects of GH on mitigating symptoms of aging (Walker, 2006).

Key Mechanism of Sermorelin

Sermorelin’s mechanism of action entails binding to specific GHRH receptors on the pituitary gland, thereby facilitating GH release (Kassem et al., 1999). GH plays an indispensable role in growth, cellular reproduction, and cell regeneration, thus contributing to human development and maintaining healthy tissue throughout the body (Rudman et al., 1990).

Sermorelin’s stimulation of GH may help alleviate some symptoms of GH deficiency such as decreased muscle mass, increased body fat, low energy, and poor sleep quality (Goddard et al., 1995).

What are the benefits of Sermorelin?

Sermorelin and Growth Hormone Deficiency: Sermorelin is employed to diagnose and treat growth hormone deficiency in children and adults. Its role in facilitating GH production can aid in managing GH deficiency symptoms such as reduced growth in children and muscle mass in adults (Goddard et al., 1995).

Sermorelin and Aging: Age-related decline in GH levels might be mitigated by Sermorelin, with potential improvements seen in symptoms like decreased energy, sleep disturbances, and increased body fat (Rudman et al., 1990).

Sermorelin and Body Composition: Sermorelin can impact body composition via GH stimulation. GH promotes fat metabolism and inhibits fat storage, contributing to body fat reduction. It also aids muscle growth, leading to an increase in lean body mass (Rudman et al., 1990).

Sermorelin and Sleep: Since GH is released in pulses that peak shortly after sleep onset, Sermorelin might enhance sleep quality by increasing GH levels (Van Cauter et al., 2000).

Sermorelin and Recovery: Sermorelin may expedite recovery from injuries and exercise due to GH’s role in cellular regeneration and repair (Crisafulli et al., 2010).

References:

  1. Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-308. doi:10.2147/ciia.2006.1.4.307
  1. Kassem M, Blum W, Ristelli J, Mosekilde L, Eriksen EF. Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro. Calcif Tissue Int. 1993 May;52(3):222-6. doi: 10.1007/BF00298725. PMID: 8513858.
  1. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990 Jul 5;323(1):1-6. doi: 10.1056/NEJM199007053230101. PMID: 2355952.
  1. Goddard AG, Covello R, Luoh SW. Review of Sermorelin Acetate. Med Lett Drugs Ther. 1995 Aug 18;37(956):91-2. PMID: 7644158.
  1. Van Cauter E, Plat L, Scharf MB, Leproult R, Cespedes S, L’Hermite-Balériaux M, Copinschi G. Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men. J Clin Invest. 1997 Aug 1;100(3):745-53. doi: 10.1172/JCI119590. PMID: 9239423; PMCID: PMC508253.
  1. Crisafulli A, Tangianu F, Tocco F, Concu A, Mameli O, Mulliri G, Caria MA. Ischemic preconditioning of the muscle improves maximal exercise performance but not maximal oxygen uptake in humans. J Appl Physiol (1985). 2011 Aug;111(2):530-6. doi: 10.1152/japplphysiol.00116.2011. Epub 2011 Jun 2. PMID: 21636567.
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