Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH) fragment Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP) [1].
It was originally developed in Russia in the 1980s as part of a government initiative to create neuroprotective agents with both cognitive-enhancing and therapeutic potential [1].
Unlike the parent ACTH peptide, Semax does not exhibit hormonal activity, which reduces concerns about systemic endocrine effects while preserving its neuromodulatory properties [1].
Research has focused on Semax primarily as a nootropic and neuroprotective compound.
It has been investigated in both preclinical and clinical contexts for conditions such as:
Because of its stability and ability to cross the blood-brain barrier, Semax has drawn attention as a candidate for regulating processes tied to neuroinflammation, oxidative stress, and neurotransmitter balance.
One of the most widely studied effects of Semax is its role in neuroprotection and cognitive function.
Preclinical studies have demonstrated that Semax influences neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF), which is essential for [2]:
In an animal study with six Wistar rats, a single intranasal spray of Semax at 50 μg/kg resulted in a 1.4 fold increase of BDNF protein levels in the hippocampus, a memory forming area of the brain. Rats were subsequently able to learn significantly more conditioned avoidance reactions (p < 0.05) [3].
An animal study of ~70 rats investigated whether Semax could counteract the negative effects of acute restraint stress on cognitive function and anxiety-related behavior. Semax was administered intraperitoneally at 0.1 mg/kg 30 minutes prior to stress exposure (electric bell sounds) [4].
Pretreatment with Semax significantly prevented stress-induced deficits in reaction time and latency, maintaining performance similar to controls (p < 0.01). Semax exposure also significantly decreased anxiety-like behavior (p < 0.04).
These effects appear to result from enhanced synaptic signaling and reduced neuronal apoptosis in regions such as the hippocampus.
In a randomized controlled trial, 110 patients who recently suffered from ischemic stroke received 6 mg of Semax twice daily for 10 days. Semax significantly increased plasma BDNF levels and was highly correlated with early rehabilitation and faster improvement of motor outcomes [5].
Overactive stress responses can induce pathogenic immune changes, which contribute to the mechanisms of diseases that may be exacerbated by stress, such as cardiovascular disease, digestive disorders, autoimmune diseases, and skin conditions. Semax has been studied for its ability to modulate stress responses and mood-related pathways.
Semax helps balance monoamine neurotransmitters, dopamine, and serotonin, which play central roles in emotional regulation and resilience to psychological stress [6]. By stabilizing these systems, Semax may mitigate the negative cognitive and behavioral consequences of chronic stress.
A rat study investigated the immunomodulatory effects of Semax during chronic social stress. After 20 days of social stress (sensory contact and daily intermale confrontations), rats were treated intranasally with Semax (150 μg/kg/day) [7].
After Semax administration, investigators observed:
Semax demonstrated immunocorrective and immunomodulatory properties in this rat model by restoring both cellular and humoral immune responses.
The findings suggest that Semax may be useful for counteracting stress-induced immune imbalance.
Semax also exerts antioxidant and anti-inflammatory effects.
Studies in PC12 cells and in rats suggest that semax may reduce markers of oxidative damage, including lipid peroxidation products, while enhancing the activity of endogenous antioxidant enzymes such as superoxide dismutase and catalase [8, 9].
These findings suggest that the peptide helps maintain redox balance during cellular stress and injuries.
Semax also modulates cytokine activity, reducing the release of pro-inflammatory mediators like TNF-α and IL-6 [10].
These actions not only limit secondary damage in ischemic injury but also contribute to preserving neuronal integrity under chronic inflammatory conditions.
Taken together, the antioxidant and anti-inflammatory properties of Semax highlight its potential relevance in research on cerebrovascular and neurodegenerative conditions.
Research Use Only. All findings described above are derived from preclinical studies (animal models and in vitro experiments). Semax is not approved by the FDA for any diagnostic or therapeutic use in humans. Genesis Peptides makes no claims regarding human clinical efficacy. This product is sold exclusively for laboratory research.
Every lot undergoes five independent assays before release. Results are published in the lot-specific Certificate of Analysis.
Every lot undergoes our 4-panel testing protocol: HPLC purity analysis, ESI-MS identity confirmation, LAL endotoxin screening, and amino acid analysis (for peptides >15 residues). Full analytical data is published in the Certificate of Analysis for each lot.
Lyophilized peptides should be stored at -20°C or below for long-term stability. Once reconstituted, peptides should be stored at 2–8°C and used within a reasonable timeframe depending on the specific compound. Avoid repeated freeze-thaw cycles. Always store in a dry environment away from direct light.
Orders placed before noon PST, Monday–Saturday, ship the same day. We offer free standard shipping on orders over $150. All orders are shipped in insulated packaging with ice packs when necessary. Standard delivery typically takes 2–4 business days within the continental US.
No. All compounds sold by Genesis Peptides are strictly for in vitro and preclinical laboratory research purposes only. They are not approved for human consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm the products will be used solely for legitimate research applications.
A Certificate of Analysis (COA) is a document issued by our analytical laboratory that reports the results of all quality control tests performed on a specific lot of product. Each COA includes HPLC chromatograms, mass spectra, endotoxin results, and amino acid analysis where applicable. COAs are available in our COA Library for every lot we have shipped.
Yes. We offer volume pricing for universities, research institutions, and laboratories with recurring needs. Discounts begin at 10+ units and scale with volume. Contact our team for a custom quote tailored to your research requirements.
FOR RESEARCH USE ONLY — Products are sold exclusively for in vitro and preclinical laboratory research. Not for human consumption or administration. Not intended for diagnostic or therapeutic use. These statements have not been evaluated by the FDA.